MeO-Suc-RPY-pNA (hydrochloride)

A neuropeptide with diverse biological activities

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库存: 现货

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促销价

数量
1mg

￥512.00

410.00

- +
5mg

￥2337.00

1870.00

- +
10mg

￥4100.00

3280.00

- +
25mg

￥9000.00

7200.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx19832
CAS: N/A
别名: Methoxy-Succinyl-Arg-Pro-Tyr-pNA, Methoxy-Succinyl-Arg-Pro-Tyr-p-nitroanilide, Serine Protease Chromogenic Substrate, S 2586
分子式: C31H40N8O9.XHCl
分子量: 668.7
纯度: >98%
溶解度: DMF: 20mg/mL,DMSO: 3mg/mL,PBS (pH 7.2): 3mg/mL
储存: Store at -20°C
库存: 现货

Background

MeO-Suc-RPY-pNA is a colorimetric substrate for serine proteases, including trypsin, chymotrypsin, kallikrein-related peptidase 7 (KLK7), and kallikrein-related peptidase 3/prostate-specific antigen.1,2,3 Serine proteases preferentially bind to and cleave the Arg-Pro-Tyr (RPY) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of serine protease activity.

|2. de Veer, S.J., Furio, L., Swedberg, J.E., et al. Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum. J. Invest. Dermatol. 137(2), 430-439 (2017).|3. Clark, M.R., Aliyar, H.A., Lee, C.W., et al. Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles. Int. J. Pharm. 413(1-2), 10-18 (2011).