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- Checkpoint Kinase (Chk)
- Dasatinib N-oxide
Dasatinib N-oxide
A major metabolite of dasatinib
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包装价格促销价数量
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1mg￥675.00540.00- +
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5mg￥3075.002460.00- +
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10mg￥5125.004100.00- +
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- 货号: ajcx19842
- CAS: 910297-52-8
- 别名: 达沙替尼N氧化物；达沙替尼杂质
- 分子式: C22H26ClN7O3S
- 分子量: 504
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: 4°C, protect from light
- 库存: 现货
Background
Dasatinib N-oxide is a major metabolite of the Abl and Src kinase inhibitor dasatinib .1 It is also a potential impurity in commercial preparations of dasatinib.2
|1. Christopher, L.J., Cui, D., Li, W., et al. Biotransformation of [14C]dasatinib: In vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys. Drug Metab. Dispos. 36(7), 1341-1356 (2008).|2. Plachká, K., ?vec, F., and Nováková, L. Ultra-high performance supercritical fluid chromatography in impurity control: Searching for generic screening approach. Anal. Chim. Acta 1039, 149-161 (2018).
