An internal standard for the quantification of meropenem
Meropenem-d6 is intended for use as an internal standard for the quantification of meropenem by GC- or LC-MS. Meropenem is a β-lactam antibiotic that is active against Gram-positive and Gram-negative bacteria (MICs = 0.008-0.13 μg/ml).1 Similar to other β-lactam antibiotics, meropenem inhibits bacterial cell wall synthesis but, in contrast to other β-lactam antibiotics, it is highly resistant to degradation by β-lactamases.1,2
|1. Edwards, J.R., Turner, P.J., Wannop, C., et al. In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I. Antimicrob. Agents Chemother. 33(2), 215-222 (1989).|2. Williams, K.J. Why monotherapy? J. Antimicrob. Chemother. 63(Suppl. 1), i18-i20 (2009).
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