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  • LH1306
LH1306的可视化放大

LH1306

A PD-1/PD-L1 interaction inhibitor

原价
¥1225-9862
价格
980-7890
LH1306的二维码

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  • 货号: ajcx20000
  • CAS: 2182653-84-3
  • 别名:
  • 分子式: C38H48N6O6
  • 分子量: 684.8
  • 纯度: >98%
  • 溶解度: DMF: 1mg/mL,DMSO: 0.25mg/mL
  • 储存: Store at -20°C
  • 库存: 现货

Background

LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 25 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 334 and 4,214 nM, respectively, in reporter assays).



|1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 protein-protein interaction. J. Med. Chem. 62(15), 7250-7263 (2019).

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