A neuropeptide with diverse biological activities
Moxidectin-d3 is intended for use as an internal standard for the quantification of moxidectin by GC- or LC-MS. Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin .1,2 It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively.2 Moxidectin (0.2 and 0.3 mg/kg) reduces worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM.3 Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.
|1. Kumar, A., Byun, H.S., Bittman, R., et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell. Signal. 23(7), 1144-1152 (2011).|2. Ranjan, S., Trudeau, C., Prichard, R.K., et al. Efficacy of moxidectin against naturally acquired nematode infections in cattle. Vet. Parasitol. 41(3-4), 227-231 (1992).|3. Ménez, C., Sutra, J.-F., Prichard, R., et al. Relative neurotoxicity of ivermectin and moxidectin in Mdr1ab (-/-) mice and effects on mammalian GABA(A) channel activity. PLoS Negl. Trop. Dis. 6(11), e1883 (2012).
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