GHRP-2 (trifluoroacetate salt)
A neuropeptide with diverse biological activities
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包装价格促销价数量
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1mg￥2775.002220.00- +
- 货号: ajcx20064
- CAS: N/A
- 别名: D-Ala-3-(2-naphthalenyl)-D-Ala-L-Ala-L-Trp-D-Phe-L-lysinamide, Growth Hormone-Releasing Peptide 2, KP-102, Pralmorelin
- 分子式: C45H55N9O6.CF3COOH
- 分子量: 932
- 纯度: ＞98%
- 溶解度: Water: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
GHRP-2 is an orally bioavailable synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.1 It induces GH release from primary rat pituitary cells (EC50 = 1.8 nM) and binds to human hypothalamic membranes (IC50 = 16 nM).2,3 GHRP-2 increases blood GH levels in anesthetized rats (ED50 = 30 nmol/kg) and serum GH levels in conscious pigs (ED50 = 0.6 nmol/kg).2 It also increases food intake and body weight gain in rats when administered at a dose of 100 μg/kg per day.4
|1. Peroni, C.N., Hayashida, C.Y., Nascimento, N., et al. Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient little mice. Clinics (Sao Paulo) 67(3), 265-272 (2012).|2. Ankersen, M., Johansen, N.L., Madsen, K., et al. A new series of highly potent growth hormone-releasing peptides derived from ipamorelin. J. Med. Chem. 41(19), 3699-3704 (1998).|3. Muccioli, G., Ghè, C., Ghigo, M.C., et al. Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland. J. Endocrinol. 157(1), 99-106 (1998).|4. Granado, M., Priego, T., Martín, A.I., et al. Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Am. J. Physiol. Endocrinol. Metab. 288(3), E486-E492 (2005).
