An internal standard for the quantification of docosanoic acid
Docosanoic acid-d43 is intended for use as an internal standard for the quantification of docosanoic acid by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.1,2 It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).3 Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase Λ activity in cell-free enzyme assays when used at a concentration of 100 μM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 μM.4 Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat and high-cholesterol diet but not a high-cholesterol only diet.5 Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
|1. Dean, L.L., and Sanders, T.H. Hexacosanoic acid and other very long-chain fatty acids in peanut seed oil. Plant Genet. Resour. 7(3), 252-256 (2009).|2. Sánchez-Machado, D.I., López-Cervantes, J., Nú?ez-Gastélum, J.A., et al. Effect of the refining process on Moringa oleifera seed oil quality. Food Chem. 187, 53-57 (2015).|3. Iijima, H., Kasai, N., Chiku, H., et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids 41(6), 521-527 (2006).|4. Yonezawa, Y., Hada, T., Uryu, K., et al. Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases. Int. J. Mol. Med. 18(4), 583-588 (2006).|5. Serviddio, G., Bellanti, F., Villani, R., et al. Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach. Redox Biol. 9, 296-305 (2016).
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