A neuropeptide with diverse biological activities
Lyso-globotetraosylceramide is a form of globotetraosylceramide (Gb4) lacking the fatty acyl group. It binds to the Shiga-like toxin pig verotoxin of edema disease (VTE) in a glycolipid binding assay.1 Lyso-globotetraosylceramide is acylated to stearic acid via a condensation reaction mediated by sphingolipid ceramide N-deacylase to form a ceramide.2 [Matreya, LLC. Catalog No. 1541]
|1. DeGrandis, S., Law, H., Brunton, J., et al. Globotetraosylceramide is recognized by the pig edema disease toxin. J. Biol. Chem. 264(21), 12520-12525 (1989).|2. Kita, K., Kurita, T., and Ito, M. Characterization of the reversible nature of the reaction catalyzed by sphingolipid ceramide N-deacylase. A novel form of reverse hydrolysis reaction. Eur. J. Biochem. 268(3), 592-602 (2001).
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