Nelfinavir-d3

An internal standard for the quantification of nelfinavir

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1mg

￥6662.00

5330.00

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货号: ajcx20232
CAS: 1217629-70-3
别名:
分子式: C32H42D3N3O4S
分子量: 570.8
纯度: >98%
溶解度: DMSO: slightly soluble,Methanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

Nelfinavir-d3 is intended for use as an internal standard for the quantification of nelfinavir by GC- or LC-MS. Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).1 It demonstrates anticancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).2 Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.

|1. Kaldor, S.W., Kalish, V.J., Davies, J.F., II, et al. Viracept (nelfinavir mesylate, AG1343): A potent, orally bioavailable inhibitor of HIV-1 protease. J. Med. Chem. 40(24), 3979-3985 (1997).|2. Shim, J.S., Rao, R., Beebe, K., et al. Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir. J. Natl. Cancer Inst. 104(20), 1576-1590 (2012).