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- ALK (Anaplastic lymphoma kinase)
- C24:1 dihydro 1-Deoxyceramide (m18:0/24:1)
C24:1 dihydro 1-Deoxyceramide (m18:0/24:1)
A very long-chain atypical ceramide
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包装价格促销价数量
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1mg￥3875.003100.00- +
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5mg￥10675.008540.00- +
- 货号: ajcx20274
- CAS: 1246298-60-1
- 别名: C24:1deoxyDHCer, C24:1 deoxyDHCeramide, C24:1 deoxy Dihydroceramide, C24:1 dihydro Ceramide (m18:0/24:1), Cer(m18:0/24:1), N-tetracosenoyl-1-deoxy-Sphinganine
- 分子式: C42H83NO2
- 分子量: 634.1
- 纯度: ＞98%
- 溶解度: DMF: 0.5 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
C24:1 dihydro 1-Deoxyceramide (m18:0/24:1) is a very long-chain atypical ceramide containing a 1-deoxysphinganine (m18:0) backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24:1 dihydro 1-Deoxyceramide (m18:0/24:1) has been found as a major 1-deoxyceramide species in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinanine-d3.3
|1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016).|2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017).|3. Alecu, I., Tedeschi, A., Behler, N., et al. Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. J. Lipid. Res. 58(1), 42-59 (2017).
