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- LH1307
LH1307
A PD-1/PD-L1 interaction inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1550.001240.00- +
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5mg￥6937.005550.00- +
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10mg￥12100.009680.00- +
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- 货号: ajcx20302
- CAS: 2375720-38-8
- 别名:
- 分子式: C54H58N8O6
- 分子量: 915.1
- 纯度: ＞98%
- 溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml,Ethanol: 10 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays).
|1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 protein-protein interaction. J. Med. Chem. 62(15), 7250-7263 (2019).
