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- Janus kinase (JAK)
- Pristanic Acid-d3
Pristanic Acid-d3
An internal standard for the quantification of pristanic acid
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包装价格促销价数量
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5mg￥5125.004100.00- +
- 货号: ajcx20332
- CAS: 1383920-14-6
- 别名: 降植烷酸
- 分子式: C19H35D3O2
- 分子量: 301.5
- 纯度: ＞98%
- 溶解度: Ethanol: soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Pristanic acid-d3 is intended for use as an internal standard for the quantification of pristanic acid by GC- or LC-MS. Pristanic acid is a saturated 19-carbon branched-chain fatty acid that has been found in human plasma.1 It can be formed from phytanic acid via α-oxidation or obtained from dietary sources.2 Pristanic acid activates peroxisome proliferator-activated receptor α (PPARα) in cell-based transactivation assays with a median EC50 value of 40 μM.1 Elevated levels of pristanic acid have been found in the plasma of patients with peroxisome biogenesis defects.2
|1. Zomer, A.W.M., van der Burg, B., Jansen, G.A., et al. Pristanic acid and phytanic acid: Naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor α. J. Lipid Res. 41(11), 1801-1807 (2000).|2. Verhoeven, N.M., and Jakobs, C. Human metabolism of phytanic acid and pristanic acid. Prog. Lipid Res. 40(6), 453-466 (2001).
