An internal standard for the quantification of pristanic acid
Pristanic acid-d3 is intended for use as an internal standard for the quantification of pristanic acid by GC- or LC-MS. Pristanic acid is a saturated 19-carbon branched-chain fatty acid that has been found in human plasma.1 It can be formed from phytanic acid via α-oxidation or obtained from dietary sources.2 Pristanic acid activates peroxisome proliferator-activated receptor α (PPARα) in cell-based transactivation assays with a median EC50 value of 40 μM.1 Elevated levels of pristanic acid have been found in the plasma of patients with peroxisome biogenesis defects.2
|1. Zomer, A.W.M., van der Burg, B., Jansen, G.A., et al. Pristanic acid and phytanic acid: Naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor α. J. Lipid Res. 41(11), 1801-1807 (2000).|2. Verhoeven, N.M., and Jakobs, C. Human metabolism of phytanic acid and pristanic acid. Prog. Lipid Res. 40(6), 453-466 (2001).
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