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An internal standard for the quantification of naftifine
Naftifine-d3 is intended for use as an internal standard for the quantification of naftifine by GC- or LC-MS. Naftifine is an allylamine compound that blocks ergosterol biosynthesis in fungi by inhibiting squalene epoxidase (Ki = 1.1 μM for C. albicans epoxidase).1
|1. Ryder, N.S., and Dupont, M.C. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem. J. 230(3), 765-770 (1985).
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