An isoflavone with diverse biological activities
Prunetin is an isoflavone that has been found in P. yedoensis and has diverse biological activities.1,2,3,4,5 It is an allosteric inhibitor of hamster liver aldehyde dehydrogenase 2 (ALDH2; IC50 = 0.45 μM) and an antagonist of the progesterone receptor when used at concentrations of 25 and 50 μM.2,3 It has estrogenic activity in MVLN cells when used at concentrations ranging from 1 to 50 μM and inhibits proliferation of MCF-7 breast cancer cells when used at 0.01 to 50 μM.4 It decreases LPS-induced increases in nitric oxide (NO) and prostaglandin E2 levels, NOS2/iNOS expression, and NF-κB activation in RAW 264.7 macrophages when used at concentrations of 50 and 100 μM.1 Prunetin (10 mg/kg) prevents LPS-induced increases in serum TNF-α, IL-1β, and IL-6 levels in a mouse model of septic shock. It also inhibits the secretion of matrix metalloproteinase-3 (MMP-3) in isolated rabbit articular chondrocytes and prevents the production of MMP-3 in the knee joint of rats in a model of osteoarthritis following administration of a 50 or 100 μM dose into the knee joint.5
|1. Gabsik, Y., Ham, I., and Choi, H.-Y. Anti-inflammatory effect of prunetin via the suppression of NF-κB pathway. Food Chem. Toxicol. 58, 124-132 (2013).|2. Lowe, E.D., Gao, G.-Y., Johnson, L.N., et al. Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J. Med. Chem. 51(15), 4482-4487 (2008).|3. Lee, J.-H., Dean, M., Austin, J.R., et al. Irilone from red clover (Trifolium pratense) potentiates progesterone signaling. J. Nat. Prod. 81(9), 1962-1967 (2018).|4. Le Bail, J.-C., Champavier, Y., Chulia, A.-J., et al. Effects of phytoestrogens on aromatase, 3β and 17β-hydroxysteroid dehydrogenase activities and human breast cancer cells. Life Sci. 66(14), 1281-1291 (2000).|5. Nam, D.C., Kim, B.K., Lee, H.J., et al. Effects of prunetin on the proteolytic activity, secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo. Korean J. Physiol. Pharmacol. 20(2), 221-228 (2016).
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