Pluviatolide

A lignan

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库存: 现货

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数量
1mg

￥2587.00

2070.00

- +
5mg

￥9625.00

7700.00

- +

已选 0 种 0 瓶

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货号: ajcx20400
CAS: 28115-68-6
别名: (-)-Pluviatolide
分子式: C20H20O6
分子量: 356.4
纯度: >98%
溶解度: DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存: Store at -20°C
库存: 现货

Background

Pluviatolide is a lignan that has been found in B. chinense and has diverse biological activities, including antioxidant, enzyme inhibitory, and antispasmodic properties.1,2,3 It scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl radicals in cell-free assays (IC50s = 23.2 and 88.5 μM, respectively).1 Pluviatolide inhibits matrix metalloproteinase-7 (MMP-7) with an IC50 value of 260 μM.2 It decreases contractions induced by acetylcholine in isolated guinea pig ileum when used at concentrations of 30 and 100 μM.3

|1. Li, D.-Q., Wang, D., Zhou, L., et al. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense. J. Asian Nat. Prod. Res. 19(5), 519-527 (2017).|2. Muta, Y., Oyama, S., Umezawa, T., et al. Inhibitory effects of lignans on the activity of human matrix metalloproteinase 7 (matrilysin). J. Agric. Food Chem. 52(19), 5888-5894 (2004).|3. Zhang, G., Shimokawa, S., Mochizuki, M., et al. Chemical constituents of Aristolochia constricta: Antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid. J. Nat. Prod. 71(7), 1167-1172 (2008).