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- Janus kinase (JAK)
- 1,2,3,4-Tetrahydrostaurosporine
1,2,3,4-Tetrahydrostaurosporine
A mutant EGFR inhibitor
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1mg￥9550.007640.00- +
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- 货号: ajcx20436
- CAS: 220038-19-7
- 别名: AFN-941
- 分子式: C28H30N4O3
- 分子量: 470.6
- 纯度: ＞98%
- 溶解度: Acetone: slightly soluble,DMSO: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
1,2,3,4-Tetrahydrostaurosporine is a derivative of staurosporine and an inhibitor of mutant EGFR (IC50 = 74 nM for EGFRT790M).1 It is selective for EGFRT790M over wild-type EGFR (IC50 = 390 nM). It also binds to Janus kinase 3 (JAK3).2
|1. Song, X., Liu, X., and Ding, X. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30(4), (2017).|2. Boggon, T.J., Li, Y., Manley, P.W., et al. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 106(3), 996-1002 (2005).
