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- Benztropine-13C-d3 (mesylate)
Benztropine-13C-d3 (mesylate)
A neuropeptide with diverse biological activities
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包装价格促销价数量
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1mg￥9237.007390.00- +
- 货号: ajcx20538
- CAS: N/A
- 别名: NSC 169913-13C-d3
- 分子式: C20[13C]H22D3NO ? CH3SO3H
- 分子量: 407.6
- 纯度: ＞98%
- 溶解度: DMSO: soluble,Methanol: soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Benztropine-13C-d3 is intended for use as an internal standard for the quantification of benztropine by GC- or LC-MS. Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).1 It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).1,2,3 Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.4 Formulations containing benztropine have been used in the management of Parkinson's disease symptoms such as involuntary tremor and dystonia.
|1. Zhang, Y., Joseph, D.B., Bowen, W.D., et al. Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues. J. Med. Chem. 44(23), 3937-3945 (2001).|2. Schmitt, K.C., Zhen, J., Kharkar, P., et al. Interaction of cocaine-, benztropine-, and GBR12909- like compounds with wildtype and mutant human dopamine transporters: Molecular features that differentially determine antagonist binding properties. J. Neurochem. 107(4), 928-940 (2008).|3. Ukairo, O.T., Bondi, C.D., Newman, A.H., et al. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. J. Pharmacol. Exp. Ther. 314(2), 575-583 (2005).|4. Kornhuber, J., Muehlbacher, M., Trapp, S., et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One 6(8), 1-13 (2011).
