A sesquiterpene
Drimendiol is a sesquiterpene that has been found in W. ugandensis.1 It inhibits C. albicans, S. aureus, and S. epidermidis biofilm formation with 50% biofilm inhibitory concentration values (BIC50s) of 25.5, 65.1, and 67.1 μg/ml, respectively. It has antifouling activity, inhibiting the settlement of C. savignyi and B. improvisus larvae on a petri dish surface (EC50s = 1 and 0.5 μg/ml, respectively).2
|1. Kipanga, P.N., Liu, M., Panda, S.K., et al. Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. J. Ethnopharmacol. 248:112352, (2020).|2. Moodie, L.W., Trepos, R., Cervin, G., et al. Probing the structure-activity relationship of the natural antifouling agent polygodial against both micro- and macrofoulers by semisynthetic modification. J. Nat. Prod. 80(2), 515-525 (2017).
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