GS-441524
An antiviral nucleoside analog
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包装价格促销价数量
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50mg￥300.00240.00- +
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100mg￥412.00330.00- +
- 货号: ajcx20636
- CAS: 1191237-69-0
- 别名:
- 分子式: C12H13N5O4
- 分子量: 291.3
- 纯度: ＞98%
- 溶解度: 10mg/mL in DMSO or in DMF
- 储存: Store at -20°C
- 库存: 现货
Background
GS-441524 is an antiviral nucleoside analog and the active metabolite of remdesivir. [1] GS-441524 is active against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) in infected primary human airway epithelial (HAE) cells (EC50s = 0.86 and 0.18 μM, respectively). It is cytoprotective against hepatitis C virus (HCV), yellow fever virus (YFV), dengue virus type 2 (DENV-2), influenza A, and parainfluenza 3 in cell-based assays (EC50s = 4.1, 11, 9.46, 27.9, and 1.71 μM, respectively).[2]
Reference:
[1]. Agostini, M.L., Andres, E.L., Sims, A.C., et al. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease. mBio 9(2), e00221-00218 (2018).
[2]. Cho, A., Saunders, O.L., Butler, T., et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg. Med. Chem. 22(8), 2705-2707 (2012).
