H-Ile-Pro-Pro-OH (trifluoroacetate salt)

具有多种生物活性的神经肽

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库存: 现货

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促销价

数量
5mg

￥550.00

440.00

- +
10mg

￥987.00

790.00

- +
25mg

￥2200.00

1760.00

- +
50mg

￥3300.00

2640.00

- +

已选 0 种 0 瓶

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货号: ajcx20642
CAS: N/A
别名: IPP
分子式: C16H27N3O4 ? XCF3COOH
分子量: 325.4
纯度: >98%
溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

H-Ile-Pro-Pro-OH (IPP) is a peptide inhibitor of angiotensin converting enzyme (ACE; IC50 = 5 μM).1 It inhibits acetylcholine-induced nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 μM and induces vasorelaxation in precontracted isolated rat aortic rings.2 IPP (0.3 mg/kg) decreases systolic blood pressure in spontaneously hypertensive, but not normotensive, rats.3 Dietary administration of IPP reduces plasma levels of total cholesterol, HDL-cholesterol, and triglycerides, mRNA expression of IL-6 and IL-1β, and aortic arch intimal thickening and atherosclerotic plaque formation in ApoE-/- mice.4

|1. Y., N., Yamamoto, N., Sakai, K., et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J. Dairy Sci. 78(4), 777-783 (1995).|2. Hirota, T., Nonaka, A., Matsushita, A., et al. Milk casein-derived tripeptides, VPP and IPP induced NO production in cultured endothelial cells and endothelium-dependent relaxation of isolated aortic rings. Heart Vessels 26(5), 549-556 (2011).|3. Nakamura, Y., Yamamoto, N., Sakai, K., et al. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. J. Dairy Sci. 78(6), 1253-1257 (1995).|4. Nakamura, T., Hirota, T., Mizushima, K., et al. Milk-derived peptides, Val-Pro-Pro and Ile-Pro-Pro, attenuate atherosclerosis development in apolipoprotein e-deficient mice: A preliminary study. J. Med. Food. 16(5), 396-403 (2013).