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- Phenelzine-d5 (sulfate)
Phenelzine-d5 (sulfate)
An internal standard for the quantification of phenelzine
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包装价格促销价数量
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500ug￥2587.002070.00- +
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1mg￥4875.003900.00- +
- 货号: ajcx20722
- CAS: 1219798-40-9
- 别名: 硫酸苯乙肼 d5 (硫酸盐)
- 分子式: C8H7D5N2 ? H2SO4
- 分子量: 239.3
- 纯度: ＞98%
- 溶解度: DMSO: soluble,Methanol: soluble,Water: soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Phenelzine-d5 (sulfate) is intended for use as an internal standard for the quantification of phenelzine by GC- or LC-MS. Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).1 It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin , and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 .2 It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.3
