Ro 41-0960

A COMT inhibitor

原价

￥650-2650

价格

￥ 520-2120

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库存: 现货

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产品引用

货号: ajcx20744
CAS: 125628-97-9
别名:
分子式: C13H8FNO5
分子量: 277.2
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 0.2 mg/ml
储存: Store at -20°C
库存: 现货

Background

Ro 41-0960 is a catechol-O-methyltransferase (COMT) inhibitor.1 It prevents dopaminergic neuron loss induced by L-DOPA in primary rat rostral mesencephalic tegmentum cultures (EC50 = 0.1 μM). Ro 41-0960 (30 mg/kg) potentiates L-DOPA and carbidopa-induced reversal of reserpine-induced akinesias in rats and reserpine-induced catalepsy and hypothermia in mice.2 It reduces striatal 3-methyl-DOPA levels and increases striatal dopamine and 3,4-dihydroxyphenylacetic acid levels in rats. Ro 41-0960 (150 mg/kg) also reduces fibroid volume in the Eker rat model of uterine fibroids.3

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生命科学

有机化学

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材料科学

Ro 41-0960

Ro 41-0960详情

Background