Sparsomycin
A bacterial metabolite with diverse biological activities
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥3000.002400.00- +
-
5mg￥11912.009530.00- +
- 货号: ajcx20764
- CAS: 1404-64-4
- 别名: 司帕索霉素
- 分子式: C13H19N3O5S2
- 分子量: 361.4
- 纯度: ＞98%
- 溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities.1,2,3 It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi.4 Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site.2 It inhibits protein synthesis in bacteria, archaea, and eukaryotes.2,3 Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.5
|1. Ottenheijm, H.C., van den Broek, L.A., Ballesta, J.P., et al. Chemical and biological aspects of sparsomycin, an antibiotic from Streptomyces. Prog. Med. Chem. 23, 219-268 (1986).|2. Wilson, D.N. The A-Z of bacterial translation inhibitors. Crit. Rev. Biochem. Mol. Biol. 44(6), 393-433 (2009).|3. Lazaro, E., Van den Broek, L.A., San Felix, A., et al. Chemical, biochemical and genetic endeavours characterizing the interaction of sparsomycin with the ribosome. Biochimie 73(7-8), 1137-1143 (1991).|4. Owen, S.P., Dietz, A., and Camiener, G.W. Sparsomycin, a new antitumor antibiotic. I. Discovery and biological properties. Antimicrob. Agents Chemother. 1962, 772-779 (1963).|5. Zylicz, Z., Wagener, D.J., van Rennes, H., et al. In vivo antitumor activity of sparsomycin and its analogues in eight murine tumor models. Invest. New Drugs 6(4), 285-292 (1988).
