A mycotoxin and AChE inhibitor
Territrem A is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 24 nM for the electric eel enzyme).1 It is toxic to mice, inducing tremors with a median tremulous dose of 0.31 mg/kg, and has an LD50 value of 17.6 mg/kg.2
|1. Chen, J.-W., and Ling, K.-H. Territrems: Naturally occurring specific irreversible inhibitors of acetylcholinesterase. J. Biomed. Sci. 3(1), 54-58 (1996).|2. Ling, K.H., Liou, H.-H., Yang, C.-M., et al. Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus. Appl. Environ. Microbiol. 47(1), 98-100 (1984).
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