A neuropeptide with diverse biological activities
The epoxygenase pathway is one of the three major branches of eicosanoid biosynthesis.1,2 However, the cytochrome P450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)17(18)-
1.Fitzpatrick, F.A., and Murphy, R.C.Cytochrome P-450 metabolism of arachidonic acid: Formation and biological actions of 'epoxygenase'-derived eicosanoidsPharmacol. Rev.40(4)229-241(1989) 2.Oliw, E.H., Bylund, J., and Herman, C.Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450Lipids31(10)1003-1021(1996) 3.Lauterbach, B., Barbosa-Sicard, E., Wang, M.H., et al.Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activatorsHypertension39(2 Pt. 2)609-613(2002)
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