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  • (±)9(10)-EpOME-d4
(±)9(10)-EpOME-d4的可视化放大

(±)9(10)-EpOME-d4

A neuropeptide with diverse biological activities

原价
¥1862-14637
价格
1490-11710
(±)9(10)-EpOME-d4的二维码

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  • 货号: ajcx20844
  • CAS: N/A
  • 别名: (±)9,10EODEd4, Leukotoxind4
  • 分子式: C18H28D4O3
  • 分子量: 300.5
  • 纯度: >98%
  • 溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

(±)9,10-EpOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry (MS). (±)9(10)-EpOME is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst.1 It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome.2 Mitochondrial dysfunction is the main feature of (±)9(10)-EpOME cytotoxicity, which may be due to the diol metabolites as well as the parent epoxide.3,4



1.Hayakawa, M., Sugiyama, S., Takamura, T., et al.Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoateBiochem. Biophys. Res. Commun.137(1)424-430(1986) 2.Ozawa, T., Hayakawa, M., Takamura, T., et al.Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxiaBiochem. Biophys. Res. Commun.134(3)1071-1078(1986) 3.Kosaka, K., Suzuki, K., Hayakawa, M., et al.Leukotoxin, a linoleate epoxide: Its implication in the late death of patients with extensive burnsMol. Cell. Biochem.139(2)141-148(1994) 4.Moran, J.H., Weise, R., Schnellmann, R.G., et al.Cytotoxicity of linoleic acid diols to renal proximal tubular cellsToxicol. Appl. Pharmacol.146(1)53-59(1997)

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