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An internal standard for the quantification of cotinine
(±)-Cotinine-d3 is intended for use as an internal standard for the quantification of cotinine by GC- or LC-MS. Cotinine is an alkaloid found in tobacco and a major metabolite of nicotine .1,2 It is formed by oxidation of nicotine by the cytochrome P450 (CYP) isoform CYP2A6.2
1.St?lhandske, T.The metabolism of nicotine and cotinine by a mouse liver preparationActa. Physiol. Scand.78(2)236-248(1970) 2.Murphy, S.E., Link, C.A., Jensen, J., et al.A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokersCancer Epidemiology, Biomarkers & Prevention13(10)1617-1623(2004)
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