(±)-Nicotine-d3

An internal standard for the quantification of (±)-nicotine

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥937.00

750.00

- +
10mg

￥1775.00

1420.00

- +
25mg

￥4162.00

3330.00

- +
50mg

￥7387.00

5910.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx20880
CAS: 69980-24-1
别名: (+/-)-氘代甲基-烟碱(甲基-2-(3-吡啶基)吡咯烷丝氨酸BETA-羟基丙氨酸)
分子式: C10H11D3N2
分子量: 165.3
纯度: >98%
溶解度: DMF: 50 mg/ml,DMSO: 30 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

(±)-Nicotine-d₃ is intended for use as an internal standard for the quantification of (±)-nicotine by GC- or LC-mass spectrometry. (±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; K_is = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.¹ (-)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (-)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.²

1.Zaveri, N., Jiang, F., Olsen, C., et al.Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluationJ. Med. Chem.53(22)8187-8191(2010) 2.Clayton, P., Lu, A., and Bishop, L.The pyrolysis of (-)-(S)-nicotine: Racemization and decompositionChirality22(4)442-446(2010)