现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • (±)-Verapamil-d3 (hydrochloride)
(±)-Verapamil-d3 (hydrochloride)的可视化放大

(±)-Verapamil-d3 (hydrochloride)

A neuropeptide with diverse biological activities

原价
¥800-6000
价格
640-4800
(±)-Verapamil-d3 (hydrochloride)的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx20890
  • CAS: N/A
  • 别名: (±)-Verapamil-d3 hydrochloride; CP-16533-1-d3 hydrochloride
  • 分子式: C27H35D3N2O4.HCl
  • 分子量: 494.1
  • 纯度: >98%
  • 溶解度: DMF: 15 mg/mL,DMSO: 10 mg/mL,Ethanol: 10 mg/mL,PBS (pH 7.2): 0.25 mg/mL
  • 储存: Store at -20°C
  • 库存: 现货

Background

(±)-Verapamil-d3 (hydrochloride) is intended for use as an internal standard for the quantification of verapamil by GC- or LC-MS. Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions.1 Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches.2,3,4 Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.5



1.Singh, B.N.The mechanism of action of calcium antagonists relative to their clinical applicationsBr. J. Clin. Pharmacol.21109S-121S(1986) 2.Dei, S., Romanelli, M.N., Scapecchi, S., et al.Verapamil analogues with restricted molecular flexibility: Synthesis and pharmacological evaluation of the four isomers of α-[1-[3-[N-[1-[2-(3,4-dimethoxy-phenyl)ethyl]]-N-methylamino]cyclohexyl]]-α-isopropyl-3,4-dimethoxybenzene-acetonitrileJournal of Medicinal Chemistry36439-445(1993) 3.Dawson, J.R., Whitaker, N.H.G., and Sutton, G.C.Calcium antagonist drugs in chronic stable angina. Comparison of verapamil and nifedipineBritish Heart Journal46508-512(2013) 4.Campbell, T.J., and Williams, K.M.Therapeutic drug monitoring: Antiarrhythmic drugsBr. J. Clin. Pharmacol.52307-319(1998) 5.Rabindran, S.K., He, H., Singh, M., et al.Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin CCancer Res.58(24)5850-5858(1998)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服