A halogenated form of lauric acid
12-Bromododecanoic acid is a halogenated form of lauric acid . It has been used in the synthesis of clickable forms of myristic acid and as a model fatty acid ligand to determine the X-ray crystal structure of bovine β-lactoglobulin-ligand complexes.1,2 12-Bromododecanoic acid (10 µg/ml) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of hepatitis B virus (HBV) infection and inhibits HIV replication in CEM-SS T cells (EC50 = 38 µM).3
1.Heal, W.P., Wickramasinghe, S.R., Leatherbarrow, R.J., et al.N-Myristoyl transferase-mediated protein labelling in vivoOrg. Biomol. Chem.6(13)2308-2315(2008) 2.Qin, B.Y., Creamer, L.K., Baker, E.N., et al.12-Bromododecanoic acid binds inside the calyx of bovine β-lactoglobulinFEBS Lett.438(3)272-278(1998) 3.Parang, K., Wiebe, L.I., Knaus, E.E., et al.In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis B virusesAntiviral Res.34(3)75-90(1997)
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