13,14-dihydro Prostaglandin E1-d4

A neuropeptide with diverse biological activities

原价

￥1725-3312

价格

￥ 1380-2650

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库存: 现货

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产品引用

货号: ajcx21090
CAS: N/A
别名: 13,14dh PGE1d4, Prostaglandin E0D4
分子式: C20H32D4O5
分子量: 360.5
纯度: >98%
溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

13,14-dihydro Prostaglandin E₁-d₄ (13,14-dh PGE₁-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh PGE₁ by GC- or LC-mass spectrometry. 13,14-dh PGE₁ is an inhibitor of ADP-induced platelet aggregation in human platelet-rich plasma and washed platelets with IC₅₀ values of 31 and 21 nM, respectively.¹ 13,14-dh PGE₁ is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE₁ which has an IC₅₀ of 40 nM.² Also, 13,14-dh PGE₁ activates adenylate cyclase in NCB-20 hybrid cells with a Kact of 668 nM.³

1.Kobzar, G., Mardla, V., J?rving, I., et al.Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed plateletsComparative Biochemistry and Physiology106(2)489-494(1993) 2.Kobzar, G., Mardla, V., J?rving, I., et al.Antiaggregating potency of E-type prostaglandins in human and rabbit plateletsProceedings of the Estonian Academy of Sciences.Chemistry40179-180(1991) 3.Blair, I.A., Hensby, C.N., and MacDermot, J.Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationshipsBr. J. Pharmac.69(3)519-525(1980)

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13,14-dihydro Prostaglandin E1-d4

13,14-dihydro Prostaglandin E1-d4详情

Background