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  2. Cyclooxygenase (COX)
  3. 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4
  • 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4
13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4的可视化放大

13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4

A neuropeptide with diverse biological activities

原价
￥1250-34737
价格
￥ 1000-27790
13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4的二维码

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  • 库存: 现货
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  • 货号: ajcx21092
  • CAS: N/A
  • 别名: 15hydroxy Lubiprostone
  • 分子式: C20H30D4F2O5
  • 分子量: 396.5
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

PGE1 is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM) and increases vasodilation.1,213,14-dihydro-16,16-difluoro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound.3,2 The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo.4 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro PGE1-3,3',4,4'-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1 by GC- or LC-mass spectrometry (MS).



1.Kobzar, G., Mardla, V., J?rving, I., et al.Antiaggregating potency of E-type prostaglandins in human and rabbit plateletsProceedings of the Estonian Academy of Sciences.Chemistry40179-180(1991) 2.Westwick, J.The effect of pulmonary metabolites of prostaglandins E1, E2 and F2α on ADP-induced aggregation of human and rabbit plateletsBritish Journal of Pharmacology58297P-298P(1976) 3.Peskar, B.A., Cawello, W., Rogatti, W., et al.On the metabolism of prostaglandin E1 administered intravenously to human volunteersJournal of Physiology and Pharmacology42327-331(1991) 4.Hatano, Y., Kohli, J.D., Goldberg, L.I., et al.Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclinProceedings of the National Academy of Sciences of the United States of America77(11)6846-6850(1980)

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