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  • 13,14-dihydro-15-keto Prostaglandin E1-d4
13,14-dihydro-15-keto Prostaglandin E1-d4的可视化放大

13,14-dihydro-15-keto Prostaglandin E1-d4

A neuropeptide with diverse biological activities

原价
¥1837-6575
价格
1470-5260
13,14-dihydro-15-keto Prostaglandin E1-d4的二维码

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  • 货号: ajcx21098
  • CAS: N/A
  • 别名: 13,14-Dh-15-k PGE1-d4
  • 分子式: C20H30O5D4
  • 分子量: 358.5
  • 纯度: >98%
  • 溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS: 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

13,14-dihydro-15-keto Prostaglandin E1-d4 (13,14-dh-15-k PGE1-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-k PGE1 by GC- or LC-mass spectrometry. 13,14-dh-15-k PGE1 is a metabolite of PGE1 with much reduced biological activity.1,2,3 Steady state plasma concentrations are about 10 pg/ml.1 13,14-dh-15-k PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 µM, respectively, compared to PGE1 which has an IC50 value of 40 nM.4



1.Leonhardt, A., Krauss, M., Gieler, U., et al.In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitisBr. J. Dermatol.136(3)337-340(1997) 2.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971) 3.Peskar, B.A., Cawello, W., Rogatti, W., et al.On the metabolism of prostaglandin E1 administered intravenously to human volunteersJournal of Physiology and Pharmacology42327-331(1991) 4.Kobzar, G., Mardla, V., J?rving, I., et al.Antiaggregating potency of E-type prostaglandins in human and rabbit plateletsProceedings of the Estonian Academy of Sciences.Chemistry40179-180(1991)

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