Background
13,14-dihydro-15-keto Prostaglandin F2α-d4 (13,14-dihydro-15-keto PGF2α-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGF2α by GC- or LC-mass spectrometry. 13,14-dihydro-15-keto PGF2α is the first prominent plasma metabolite of PGF2α in the 15-hydroxy PGDH pathway.1 Measurement of 13,14-dihydro-15-keto PGF2α in plasma can be used as a marker of the in vivo production of PGF2α.1,2,3
1.Samuelsson, B., Goldyne, M., Granstr?m, E., et al.Prostaglandins and thromboxanesAnnu. Rev. Biochem.47997-1029(1978)
2.Del Vecchio, R.P., Maxey, K.M., and Lewis, G.S.A quantitative solid-phase enzymeimmunoassay for 13,14-dihydro-15-keto-prostaglandin F2α in plasmaProstaglandins43(4)321-330(1992)
3.Meyer, H.H.D., Eisele, K., and Osaso, J.A biotin-streptavidin amplified enzyme immunoassay for 13,14-dihydro-15-keto-PGF2αProstaglandins38(3)375-383(1989)
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