13,14-dihydro-16,16-difluoro Prostaglandin D2

A neuropeptide with diverse biological activities

原价

￥637-5087

价格

￥ 510-4070

13,14-dihydro-16,16-difluoro Prostaglandin D2的二维码

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库存: 现货

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产品引用

货号: ajcx21106
CAS: N/A
别名:
分子式: C20H32F2O5
分子量: 390.5
纯度: >98%
溶解度: DMF: 14 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 15 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin D₂ (PGD₂) plays important roles in vascular smooth muscle relaxation, the inhibition of platelet aggregation, and anaphylaxis. 13,14-dihydro-16,16-difluoro PGD₂ is an analog of PGD₂. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.¹ Importantly, 13,14-dihydro PGE₁ has activity that is comparable to that of PGE₁, suggesting that this analog of PGD₂ could be biologically active.^2,3

1.Hatano, Y., Kohli, J.D., Goldberg, L.I., et al.Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclinProceedings of the National Academy of Sciences of the United States of America77(11)6846-6850(1980) 2.?ngg?rd, E.The biological activities of three metabolites of prostaglandin E1Acta Physiologica Scandinavica66509-510(1966) 3.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971)

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13,14-dihydro-16,16-difluoro Prostaglandin D2

13,14-dihydro-16,16-difluoro Prostaglandin D2详情

Background