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  • 13,14-dihydro-16,16-difluoro Prostaglandin D2
13,14-dihydro-16,16-difluoro Prostaglandin D2的可视化放大

13,14-dihydro-16,16-difluoro Prostaglandin D2

A neuropeptide with diverse biological activities

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13,14-dihydro-16,16-difluoro Prostaglandin D2的二维码
  • 库存: 现货
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  • 100ug
    ¥637.00
    510.00
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  • 500ug
    ¥2887.00
    2310.00
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  • 1mg
    ¥5087.00
    4070.00
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  • 货号: ajcx21106
  • CAS: N/A
  • 别名:
  • 分子式: C20H32F2O5
  • 分子量: 390.5
  • 纯度: >98%
  • 溶解度: DMF: 14 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 15 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Prostaglandin D2 (PGD2) plays important roles in vascular smooth muscle relaxation, the inhibition of platelet aggregation, and anaphylaxis. 13,14-dihydro-16,16-difluoro PGD2 is an analog of PGD2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.1 Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGD2 could be biologically active.2,3



1.Hatano, Y., Kohli, J.D., Goldberg, L.I., et al.Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclinProceedings of the National Academy of Sciences of the United States of America77(11)6846-6850(1980) 2.?ngg?rd, E.The biological activities of three metabolites of prostaglandin E1Acta Physiologica Scandinavica66509-510(1966) 3.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971)

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