A neuropeptide with diverse biological activities
15-deoxy-δ12,14-Prostaglandin J2-d9 (15-deoxy-δ12,14-PGJ2-d9) is intended for use as an internal standard for the quantification of 15-deoxy-δ12,14-PGJ2 by GC- or LC-MS. 15-deoxy-δ12,14-PGJ2 is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 15-deoxy-δ12,14-PGJ2 is more potent than PGD2, δ12-PGJ2 , and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1
1.Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al.A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiationCell83(5)813-819(1995) 2.Forman, B.M., Tontonoz, P., Chen, J., et al.15-Deoxy-δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγCell83(5)803-812(1995)
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