17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

A prostaglandin F derivative similar to latanoprost free acid

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1mg

￥1175.00

940.00

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5mg

￥5162.00

4130.00

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10mg

￥9200.00

7360.00

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货号: ajcx21160
CAS: 294856-01-2
别名: 17trifluoromethylphenyl13,14dihydro trinor PGF2α
分子式: C24H33O5F3
分子量: 458.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

A number of 17-phenyl trinor prostaglandin F_2α (17-phenyl trinor PGF_2α) derivatives have been approved for the treatment of glaucoma.^1,2,3 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.⁴ 17-trifluoromethylphenyl-13,14-dihydro trinor PGF_2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF_2α would act very much like the free acid of latanoprost.

1.Woodward, D.F., Krauss, A.H.P., Chen, J., et al.The pharmacology of Bimatoprost (LumiganTM)Survey of Ophthalmology45S337-S345(2001) 2.Stjernschantz, J.W.From PGF2α-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lectureInvestigative Ophthalmology & Visual Science42(6)1134-1145(2001) 3.Sorbera, L.A., and Casta?er, J.TravoprostDrugs Future25(1)41-45(2000) 4.Resul, B., Stjernschantz, J., No, K., et al.Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agentsJournal of Medicinal Chemistry36243-248(1993)