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- HSP (Heat shock proteins)
- 2-Fluoroadenine
2-Fluoroadenine
A heterocyclic building block
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包装价格促销价数量
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250mg￥600.00480.00- +
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500mg￥1150.00920.00- +
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1g￥1925.001540.00- +
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- 货号: ajcx21266
- CAS: 700-49-2
- 别名: 2-氟-6-氨基嘌呤
- 分子式: C5H4FN5
- 分子量: 153.1
- 纯度: ＞98%
- 溶解度: DMSO: slightly soluble,Ethanol: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro.1 It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 µM.2
1.Llauger, L., He, H., Kim, J., et al.Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90J. Med. Chem.48(8)2892-2905(2005) 2.Parker, W.B., Allan, P.W., Shaddix, S.C., et al.Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cellsBiochem. Pharmacol.55(10)1673-1681(1998)
