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- HSP (Heat shock proteins)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
A heterocyclic building block
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包装价格促销价数量
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1g￥1012.00810.00- +
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5g￥3287.002630.00- +
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10g￥125.00100.00- +
- 货号: ajcx21362
- CAS: 214360-73-3
- 别名: 4-氨基苯硼酸频哪醇酯
- 分子式: C12H18BNO2
- 分子量: 219.1
- 纯度: ＞98%
- 溶解度: DMF: 20mg/mL,DMF:PBS (pH 7.2) (1:5): 0.16mg/mL,DMSO: 10mg/mL,Ethanol: 3mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline is a heterocyclic building block.1,2 It has been used in the synthesis of 3-aminoindazole-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity and roscovitine derivatives that are dual inhibitors of cyclin-dependent kinases (CDKs) and casein kinase 1 (CK1).
1.Dai, Y., Hartandi, K., Ji, Z., et al.Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitorJ. Med. Chem.50(7)1584-1597(2007) 2.Paraiso, K.H.T., Haarberg, H.E., Wood, E., et al.The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanismsClin. Cancer Res.18(9)2502-2514(2012)
