5-Methoxycanthinone

An alkaloid with anticancer properties

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥3500.00

2800.00

- +
5mg

￥13750.00

11000.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties.¹ It is cytotoxic to KB, A549, and HCT-8 cells (EC₅₀s = 2.9, 3.1, and 2.5 µg/ml, respectively). It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1 (IC₅₀s = 10.4 and 5.1 µg/ml, respectively).² However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.³

1.Xu, Z., Chang, F.R., Wang, H.-K., et al.Anti-HIV agents 45 and antitumor agents 205. Two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridanaJ. Nat. Prod.63(12)1712-1715(2000) 2.Cebrián-Torrejón, G., Spelman, K., Leblanc, K., et al.The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. Angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparumRevista Brasileira de Farmacognosia21(4)652-661(2011) 3.Ferreira, M.E., Rojas de Arias, A., Torres de Ortiz, S., et al.Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. angustifoliumJ. Ethnopharmacol.80(2-3)199-202(2002)