Background
5'-N-Etlcarboxamidoadenosine (NECA) is an adenosine analog that acts as an agonist of adenosine receptors (Kis = 1,880, 6,660, and 3.5 nM for human adenosine subtypes A1, A2A, and A3, respectively).1 NECA is reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC50 = 3.1 μM).2,3
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