6-Chloro-2-fluoropurine

A heterocyclic building block

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250mg

￥600.00

480.00

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1g

￥1212.00

970.00

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货号: ajcx21498
CAS: 1651-29-2
别名: 2-氟-6-氯嘌呤
分子式: C5H2ClFN4
分子量: 172.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存: Store at -20°C
库存: 现货

Background

6-Chloro-2-fluoropurine is a heterocyclic building block.^1,2 It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro.¹ 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.²

1.Wilson, S.C., Atrash, B., Barlow, C., et al.Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitorsBioorg. Med. Chem.19(22)6949-6965(2011) 2.Lee, K., Choi, Y., Gullen, E., et al.Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2',3'-unsaturated L-nucleosidesJ. Med. Chem.42(7)1320-1328(1999)