6-Hydroxypyridin-3-ylboronic Acid

A heterocyclic building block

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库存: 现货

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100mg

￥1212.00

970.00

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250mg

￥2887.00

2310.00

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500mg

￥5450.00

4360.00

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货号: ajcx21504
CAS: 903899-13-8
别名:
分子式: C5H6BNO3
分子量: 138.9
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml,Ethanol: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.^1,2 It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).¹ 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.²

1.Hendricks, R.T., Spencer, S.R., Blake, J.F., et al.3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymeraseBioorg. Med. Chem. Lett.19(2)410-414(2009) 2.Verheijen, J.C., Richard, D.J., Curran, K., et al.Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and sselective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 6-aryl substituentJ. Med. Chem.52(24)8010-8024(2009)