A neuropeptide with diverse biological activities
7α-hydroxy-4-Cholesten-3-one-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy-4-cholesten-3-one by GC- or LC-MS. 7α-hydroxy-4-Cholesten-3-one is a metabolite of 7α-hydroxy cholesterol and an intermediate in the biosynthesis of bile acids.1 Plasma levels of 7α-hydroxy-4-cholesten-3-one positively correlate with the rate of bile acid synthesis in humans and are increased in patients following ileal resection.2
1.Russell, D.W.The enzymes, regulation, and genetics of bile acid synthesisAnnu. Rev. Biochem.72137-174(2003) 2.Axelson, M., Aly, A., and Sj?vall, J.Levels of 7α-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in manFEBS Lett.239(2)324-328(1988)
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