8-iso Prostaglandin E2-d4

A neuropeptide with diverse biological activities

原价

￥2750-9837

价格

￥ 2200-7870

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库存: 现货

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产品引用

货号: ajcx21536
CAS: N/A
别名: 8<span class=\foreign\>epi</span> PGE2d4, 8 PGE2d4
分子式: C20H28D4O5
分子量: 356.5
纯度: >98%
溶解度: DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS (pH 7.2): >5 mg/ml
储存: Store at -20°C
库存: 现货

Background

8-iso Prostaglandin E₂-d₄ (8-iso PGE₂-d₄) contains four deuterium atoms at the hydroxyethyl 3, 3',4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGE₂ by GC- or LC-mass spectrometry. 8-iso PGE₂ is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.¹ It is a potent renal vasoconstrictor in the rat.^1,2 8-iso PGE₂ inhibits U-46619 or I-BOP-induced platelet aggregation with IC₅₀ values of 0.5 and 5 µM, respectively.³ When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-iso PGE₂ decreases the GFR and renal plasma flow by 80% without affecting blood pressure.¹

1.Morrow, J.D., Minton, T.A., Mukundan, C.R., et al.Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanesThe Journal of Biological Chemisty2694317-4326(1994) 2.Hoffman, S.W., Moore, S., and Ellis, E.F.Isoprostanes: Free radical-generated prostaglandins with constrictor effects on cerebral arteriolesStroke28844-884(1997) 3.Longmire, A.W., Roberts, L.J., and Morrow, J.D.Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptorProstaglandins48247-256(1994)

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信号通路

生命科学

有机化学

无机化学

材料科学

8-iso Prostaglandin E2-d4

8-iso Prostaglandin E2-d4详情

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