Ac-LEHD-pNA (trifluoroacetate salt)

A neuropeptide with diverse biological activities

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库存: 现货

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1mg

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货号: ajcx21604
CAS: N/A
别名: Ac-Leu-Glu-His-Asp-pNA, Caspase-9 Chromogenic Substrate I
分子式: C29H38N8O11.XCF3COOH
分子量: 674.7
纯度: >98%
溶解度: Water: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Ac-LEHD-pNA is a substrate for caspase-9.¹ Caspase-9 preferentially binds to and cleaves the Leu-Glu-His-Asp (LEHD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.^1,2,3

1.Hsu, Y.L., Kuo, P.L., Lin, L.T., et al.Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cellsJournal of Pharmacology and Experimental Therapeutics313(1)333-344(2005) 2.Por?ba, M., Stró?yk, A., Salvesen, G.S., et al.Caspase substrates and inhibitorsCold Spring Harb. Perspect. Biol.5(8)A008680(2013) 3.Yu, M.-S., Suen, K.-C., Kwok, N.-S., et al.Beta-amyloid peptides induces neuronal apoptosis via a mechanism independent of unfolded protein responsesApoptosis11(5)687-700(2006)