Background
Arachidonic acid-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of arachidonic acid by GC- or LC-mass spectrometry. Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways.1 Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signaling and inflammation.2
1.Burgoyne, R.D., and Morgan, A.The control of free arachidonic acid levelsTrends Biochem. Sci.15(10)365-366(1990)
2.Nixon, A.B., Greene, D.G., and Wykle, R.L.Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophilsBiochim. Biophys. Acta.1300(3)187-196(1996)
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