Arachidonoyl Ethanolamide-d8

An internal standard for the quantification of arachidonoyl ethanolamide

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库存: 现货

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100ug

￥787.00

630.00

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500ug

￥3550.00

2840.00

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1mg

￥6237.00

4990.00

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5mg

￥27050.00

21640.00

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货号: ajcx21712
CAS: 924894-98-4
别名: AEAd8, Anandamided8
分子式: C22H29D8NO2
分子量: 355.6
纯度: >98%
溶解度: 1 mg/ml EtOH:PBS pH 7.2: can dilute 1:1.6 (>380 μg/ml),10 mg/ml EtOH:PBS pH 7.2: can dilute 1:1 (>5 mg/ml)
储存: Store at -20°C
库存: 现货

Background

Arachidonoyl ethanolamide-d₈ (AEA-8) contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of AEA by GC- or LC-mass spectrometry. AEA is the ethanolamine amide of arachidonic acid, first isolated from porcine brain.¹ It is an endogenous cannabinoid neurotransmitter that binds to both CB₁ and CB₂ receptors.² AEA inhibits the specific binding of [³H]-HU-243 to synaptosomal membranes with a K_i value of 52 nM, compared to 46 nM for δ⁹-THC.¹

1.Devane, W.A., Hanus, L., Breuer, A., et al.Isolation and structure of a brain constituent that binds to the cannabinoid receptorScience258(5090)1946-1949(1992) 2.Felder, C.C., Briley, E.M., Axelrod, J., et al.Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transductionProc. Natl. Acad. Sci. U.S.A.90(16)7656-7660(1993)