Argatroban-d3 (hydrochloride)

An internal standard for the quantification of argatroban

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库存: 现货

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数量
1mg

￥5025.00

4020.00

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5mg

￥22425.00

17940.00

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货号: ajcx21718
CAS: 1356847-56-7
别名: 阿加曲班杂质23
分子式: C23H33D3N6O5S.HCl
分子量: 548.1
纯度: >98%
溶解度: DMF: soluble,DMSO: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

Argatroban-d₃ is intended for use as an internal standard for the quantification of argatroban by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC₅₀s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).¹ It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (K_is = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC₅₀ value of 0.077 µM.² Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.

1.Park, H.D., Lee, S.H., Kim, T.H., et al.Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrugBioorganic & Medicinal Chemistry Letters23(17)4779-4784(2013) 2.Kato, Y., Kita, Y., Hirasawa-Taniyama, Y., et al.Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pigEur. J. Pharmacol.473(2-3)163-169(2003)