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  • Artemether-d3
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Artemether-d3

An internal standard for the quantification of artemether

原价
¥800-6400
价格
640-5120
Artemether-d3的二维码

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  • 货号: ajcx21722
  • CAS: 93787-85-0
  • 别名: 蒿甲醚-D3,Dihydroqinghaosu methyl ether-d3; Dihydroartemisinin methyl ether-d3; SM224-d3
  • 分子式: C16H23D3O5
  • 分子量: 301.4
  • 纯度: >98%
  • 溶解度: Chloroform: soluble,Methanol: soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Artemether-d3 is intended for use as an internal standard for the quantification of artemether by GC- or LC-MS. Artemether is an antiparasitic agent and a derivative of artemisinin .1 It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively).2 Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively.3 It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg.1 Formulations containing artemether have been used in the treatment of malaria.



1.Xiao, S.H., and Catto, B.A.In vitro and in vivo studies of the effect of artemether on Schistosoma mansoniAntimicrob. Agents Chemother.33(9)1557-1562(1989) 2.Pillai, D.R., Lau, R., Khairnar, K., et al.Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infectionsMalar. J.11131(2012) 3.Shmuklarsky, M.J., Klayman, D.L., Milhous, W.K., et al.Comparison of β-artemether and β-arteether against malaria parasites in vitro and in vivoAm. J. Trop. Med. Hyg.48(3)377-384(1993)

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